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Trial & Error

24 articles

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Empirical

Technical Note: A GBLUP to Produce ssGBLUP Solutions for Genotyped Animals

Mohammad Ali Nilforooshan

Nowadays, single-step genomic best linear unbiased prediction (ssGBLUP) is the most popular methodology for livestock genetic evaluation. It simultaneously evaluates genotyped and nongenotyped animals using an augmented genotype and pedigree relationship matrix. In most livestock species, a small…

doi:10.36850/429a-ac1dRead
Empirical

Attempt to Identify Extracellular Vesicles Derived From the Blood-Brain Barrier in Peripheral Blood

Mette Elise Tunset, Francis Combes & Hanne Haslene-Hox

The blood-brain barrier (BBB) is hypothesized to play a role in the pathophysiology of psychosis. However, studying this structure in living humans is challenging due to limitations in current methods that fail to identify subtle changes or dysfunctions. We aimed to develop a method to isolate…

doi:10.36850/3738-4936Read
Empirical

Partial Endothelial Trepanation versus Deep Anterior Lamellar Keratoplasty in keratoconus patients: Results of the PENTACON trial

Robert P.L. Wisse, Cathrien A. Eggink, Bart T.H. van Dooren & Allegonda van der Lelij

The purpose of this research was to report on the surgical safety and outcomes of two distinct techniques of anterior lamellar corneal surgery: the Big Bubble Deep Anterior Lamellar Keratoplasty (DALK) versus Busin’s Partial ENdothelial Trepanation (PET) in addition to anterior lamellar keratoplasty…

doi:10.36850/0550-4e9cRead
Empirical

The Impact of Incentivization on Recruitment, Retention, Data Quality, and Participant Characteristics in Ecological Momentary Assessments

Helge Giese & Laura M König

Ecological Momentary Assessment (EMA) study participation is usually incentivized using monetary (e.g., fixed or performance-contingent payment) or non-monetary (e.g., feedback) compensation. This study investigates the impact of this incentivization on recruitment, retention, data quality, and…

doi:10.36850/28b4-4f59Read
Empirical

Preclinical Assessment of a Cannabinoid CB2 Receptor Antagonist in a Murine Model of Cerebral Malaria

Ana Borrego Escartín, María Gómez-Cañas, Soledad García Gómez-Heras, Patricia Marín-García, Javier Fernández-Ruiz & Amalia Diez

Malaria is a most important parasitic disease due to its highest impact worldwide. It results in around 200 million clinical cases and 0,5-1 million deaths per year, mainly due to cerebral malaria (CM), a life-threatening neurological syndrome that predominantly affects predominantly children under…

doi:10.36850/e10Read
Empirical

Cognitive Functions, Mood and Sleep Quality after Two Months of Intermittent Fasting

Maja Batorek & Ivana Hromatko

Intermittent fasting is being popularized as a method beneficial not only for weight loss, but also for overall psychological functioning and well-being. However, there is only a handful of studies examining the latter claims. The aim of this open-label study was to contribute to the understanding…

doi:10.36850/e71f-5cffRead
Empirical

Smile, You’re on Camera: Investigating the Relationship between Selfie Smiles and Distress

Monika N. Lind, Michelle L. Byrne, Sean Devine & Nicholas B. Allen

Background : This study examined the relationship between (1) participant smiling in daily “selfie” videos and (2) self-reported distress. Given the extensive use of digital devices for sharing expressions of non-verbal behavior, and some speculation that these expressions may reveal psychological…

doi:10.36850/8716-5abeRead
Empirical

Empathic Accuracy, Mindfulness, and Facial Emotion Recognition: An Experimental Study

Marije aan het Rot, Merle-Marie Pittelkow, D. Elisabeth Eckardt, Nils Simonsen & Brian D. Ostafin

Background and Objectives: Empathic accuracy, i.e., the degree to which one is able to accurately infer the emotions of others, may be acutely malleable. We examined this idea by testing the immediate effect of a brief mindfulness intervention or facial emotion recognition training. Methods:…

doi:10.36850/e17Read
Empirical

Prenatal Sildenafil and Fetal-placental Programming in Human Pregnancies Complicated by Fetal Growth Restriction: A Retrospective Gene Expression Analysis

Fieke Terstappen, Torsten Plösch, Jorg J.A. Calis, Wessel Ganzevoort, Anouk Pels, Nina D. Paauw, Sanne J. Gordijn, Bas B. van Rijn, Michal Mokry & A. Titia Lely

Objective: Fetal growth restricted (FGR) offspring are more susceptible to develop cardiovascular and renal disease. The potential therapeutic value of sildenafil to improve fetal growth has recently been evaluated in several randomized clinical trials. Here we investigate whether administration of…

doi:10.36850/e16Read
Empirical

Medical Expert Endorsement Fails to Reduce Vaccine Hesitancy in U.K. Residents

Folco Panizza, Piero Ronzani, Carlo Martini, Lucia Savadori & Matteo Motterlini

In this report we outline the null findings of a pre-registered experiment on vaccine hesitancy in the United Kingdom. The experiment targeted vaccine misconceptions common among participants by presenting a correction to such claims endorsed by a group of medical experts. The experiment had the aim…

doi:10.36850/e15Read
Empirical

Challenges of Using Signaling Data From Telecom Network in Non-Urban Areas

Håvard Toft, Alexey Sirotkin, Markus Landrø, Rune Verpe Engeset & Jordy Hendrikx

Outdoor recreation continues to increase in popularity. In Norway, several avalanche fatalities are recorded every year, but the accurate calculation of a fatal accident rate is impossible without knowing how many people are exposed. We attempted to employ signaling data from telecom network data to…

doi:10.36850/e14Read
Empirical

Driven to Snack: Simulated Driving Increases Subsequent Consumption

Floor van Meer, Stephen Murphy, Wilhelm Hofmann, Henk van Steenbergen & Lotte F. van Dillen

When individuals eat while distracted, they may compensate by consuming more afterwards. Here, we examined the effect of eating while driving, and explored potential underlying mechanisms. Participants (N = 116, 73.3% female) were randomly allocated to complete a driving simulation (distraction…

doi:10.36850/e13Read
Empirical

Gamified Inoculation Against Misinformation in India: A Randomized Control Trial

Trisha Harjani, Melisa-Sinem Basol, Jon Roozenbeek & Sander van der Linden

Although the spread of misinformation is a pervasive and disruptive global problem, extant research is skewed towards “WEIRD” countries leaving questions about how to tackle misinformation in the developing world with different media and consumption patterns unanswered. We report the results of a…

doi:10.36850/e12Read
Empirical

No Meaningful Difference in Attentional Bias Between Daily and Non-Daily Smokers

James Bartlett, Rebecca Jenks & Nigel Wilson

Both daily and non-daily smokers find it difficult to quit smoking long-term. One factor associated with addictive behavior is attentional bias, but previous research in daily and non-daily smokers found inconsistent results and did not report the reliability of their cognitive tasks. Using an…

doi:10.36850/e11Read
Empirical

Do Carryover Effects Influence Attentional Bias to Threat in the Dot-Probe Task?

Joshua W. Maxwell, Lin Fang & Joshua M. Carlson

Threatening stimuli are often thought to have sufficient potency to bias attention, relative to neutral stimuli. Researchers and clinicians opt for frequently used paradigms to measure such bias, such as the dot-probe task. Bias to threat in the dot-probe task is indicated by a congruency effect…

doi:10.36850/e9Read
Empirical

Classical Conditioning for Pain: The Development of a Customized Single-Case Experimental Design

Tamal Kumar De, Victoria J. Madden, Johan W. S. Vlaeyen & Patrick Onghena

Single-case experiments are increasingly popular in the behavioral sciences. Due to their flexibility, single-case designs can be customized to test a variety of experimental hypotheses. We were interested in using a single-case experimental approach to test whether pain thresholds can be influenced…

doi:10.36850/e8Read
Empirical

The Gloria Adherence Subproject: Problems and Randomization Mistakes

Linda Hartman, Marc R. Kok, Esmeralda Molenaar, Ed N. Griep, Jaap M. Van Laar, Jan Maarten Van Woerkom, Cornelia F. Allaart, Hennie G. Raterman, Yvonne P. M. Ruiterman, Marieke J. H. Voshaar, João Redol, Rui M. A. Pinto, L. Thomas Klausch, Willem F. Lems & Maarten Boers

Medication adherence, which is the extent to which patients take their medication as prescribed, is essential in treating chronic inflammatory diseases such as rheumatoid arthritis (RA). Therefore, we nested a subproject in the two-year multicenter Glucocorticoid Low-dose Outcome in Rheumatoid…

doi:10.36850/e6Read
Empirical

Rewilding Cognition: Complex Dynamics in Open Experimental Systems

Wendy Ross & Frédéric Vallée-Tourangeau

Insight problems are sometimes designed to encourage an incorrect and misleading interpretation that veils a simple answer. The socks problem is one such problem: Given black socks and brown socks in a drawer mixed in a ratio of four to five, how many socks will you have to take out to make sure…

doi:10.36850/e4Read
Empirical

The Complexity of Joint Regeneration: How an Advanced Implant Could Fail by Its In Vivo Proven Bone Component

Paweena Diloksumpan, Florencia Abinzano, Mylène de Ruijter, Anneloes Mensinga, Saskia Plomp, Ilyas Khan, Harold Brommer, Ineke Smit, Miguel Dias Castilho, P. René van Weeren, Jos Malda & Riccardo Levato

Articular cartilage damage is a major challenge in healthcare due to the lack of long-term repair options. There are several promising regenerative implant-based approaches for the treatment, but the fixation of the implant remains a significant challenge. This study evaluated the potential for…

doi:10.36850/e3Read
Empirical

Trial and Error (-Related Negativity): An Odyssey of Integrating Different Experimental Paradigms

Juliane Traxler, Roxane V. Philips, Andreas von Leupoldt & Johan W. S. Vlaeyen

Pain can be considered as a signal of “bodily error”: Errors — discrepancies between the actual and optimal/targeted state — can put organisms in danger and activate behavioral defensive systems. If the error relates to the body, pain is the warning signal that motivates protective action such as…

doi:10.36850/e2Read
Empirical

Alcohol Cues and their Effects on Sexually Aggressive Thoughts

Julie Leboeuf, Stine Linden-Andersen & Jonathan Carriere

Alcohol and its effects on aggression have been the subject of many discussions and research papers. Despite this fact, there is still a debate surrounding what it is exactly about alcohol that causes aggression. The current study sought to replicate the past finding by Bartholow and Heinz (2006),…

doi:10.36850/e1Read