15 articles
All articlesStefan Gaillard, Stefan van Geelen, Elvire Landstra & Arno Hoes
Uncertainty is a daily reality in the health domain. Clinicians routinely face it when diagnosing patients, predicting outcomes, and selecting treatments in partnership with patients. Patients and their families, in turn, experience uncertainty about their condition and what the future may hold.…
Carsten F.J. Bakhuis & Marcel A.G. van der Heyden
In this reflection article, we evaluate a sub study of the STRIDER trial by Terstappen et al., which investigated the molecular effects of prenatal sildenafil administration in pregnancies complicated by fetal growth restriction (FGR). Unfortunately, this trial revealed no clinical benefit and even…
Falk Hübner, Gjilke Keuning & Marijke Lucas
In this article, the authors reflect on the co-creative processes of three artistic research residencies in an elderly care institution in Leiden, The Netherlands. The artists were asked to immerse themselves in the institution for half a year, 2 days a week, to carry out practice-based and…
Robert P. L. Wisse
As a clinician-scientist, the journey through the PENTACON trial, a multicenter randomized clinical study comparing two surgical techniques for corneal transplantation in keratoconus patients, was both enlightening and challenging. The study, which served as the centerpiece of my PhD research in…
Robert P.L. Wisse, Cathrien A. Eggink, Bart T.H. van Dooren & Allegonda van der Lelij
The purpose of this research was to report on the surgical safety and outcomes of two distinct techniques of anterior lamellar corneal surgery: the Big Bubble Deep Anterior Lamellar Keratoplasty (DALK) versus Busin’s Partial ENdothelial Trepanation (PET) in addition to anterior lamellar keratoplasty…
Berent Prakken
“Boys we were - but good boys. If I may say so myself. We’re much smarter now, so smart it’s pathetic.” (Nescio, 2012)
Martijn van der Meer
Expert endorsement seems a promising tool in countering vaccine hesitancy. Yet findings from an experiment in the United Kingdom, published in this journal, found that repeated expert‐backed “debunking” messages had little effect on vaccination intentions or behaviors. At the same time, a similar…
Anne Margit Reitsema, Sanne Nijhof & Odilia Laceulle
Part of Special Issue: Scientific Failure and Uncertainty in the Health Domain.
Maja Batorek & Ivana Hromatko
Intermittent fasting is being popularized as a method beneficial not only for weight loss, but also for overall psychological functioning and well-being. However, there is only a handful of studies examining the latter claims. The aim of this open-label study was to contribute to the understanding…
Stephan Schleim
Intermittent fasting has received increasing scientific and public attention in recent years. The study by Batorek et al. investigated whether time-restricted feeding, a form of intermittent fasting, improves cognitive performance and subjective-emotional well-being. This commentary discusses the…
Monika N. Lind, Michelle L. Byrne, Sean Devine & Nicholas B. Allen
Background : This study examined the relationship between (1) participant smiling in daily “selfie” videos and (2) self-reported distress. Given the extensive use of digital devices for sharing expressions of non-verbal behavior, and some speculation that these expressions may reveal psychological…
Sigrid E. M. Heinsbroek, Vincent Bontrop, Rutger P. Chorus & C. Michel Zwaan
The rationale behind a Medical Research Ethics Committee (MREC) negative decision is always shared directly with the applicants. However, insight into the review process and common reasons for a negative decision may also be valuable for other researchers, clinical research organizations and people…
Fieke Terstappen, Torsten Plösch, Jorg J.A. Calis, Wessel Ganzevoort, Anouk Pels, Nina D. Paauw, Sanne J. Gordijn, Bas B. van Rijn, Michal Mokry & A. Titia Lely
Objective: Fetal growth restricted (FGR) offspring are more susceptible to develop cardiovascular and renal disease. The potential therapeutic value of sildenafil to improve fetal growth has recently been evaluated in several randomized clinical trials. Here we investigate whether administration of…
Folco Panizza, Piero Ronzani, Carlo Martini, Lucia Savadori & Matteo Motterlini
In this report we outline the null findings of a pre-registered experiment on vaccine hesitancy in the United Kingdom. The experiment targeted vaccine misconceptions common among participants by presenting a correction to such claims endorsed by a group of medical experts. The experiment had the aim…
David Grüning
Rapid technological development allows for ever new opportunities to nudge individuals’ behavior and knowledge digitally. The Gloria Adherence Subproject by Hartman et al. (2022) implements such a digital nudge via a mobile device aiming at medication adherence. Besides methodological and practical…
